- 42,266
- 177,005
- Joined
- Oct 28, 2013
Hide Ya Wives, Hide Ya Kids: Worldwide Coronavirus Pandemic!
- 12,060
- 14,872
- Joined
- Jul 27, 2013
- 42,266
- 177,005
- Joined
- Oct 28, 2013
sonoftony
Supporter
- 29,016
- 23,123
- Joined
- Apr 3, 2005
expecting a big spike in Palm Beach
- 12,060
- 14,872
- Joined
- Jul 27, 2013
- 42,266
- 177,005
- Joined
- Oct 28, 2013
sonoftony
Supporter
- 29,016
- 23,123
- Joined
- Apr 3, 2005
not a good start to my morning so far. Just found out my cuz lost 2 of his uncles on his mother's side 
- 12,060
- 14,872
- Joined
- Jul 27, 2013
- 12,060
- 14,872
- Joined
- Jul 27, 2013
*If large corps are failing, no way small biz will return
- 141,328
- 168,127
- Joined
- Mar 16, 2010
- 12,060
- 14,872
- Joined
- Jul 27, 2013
- 149,197
- 198,056
- Joined
- Mar 30, 2007
- 12,060
- 14,872
- Joined
- Jul 27, 2013
Site-specific glycan analysis of the SARS-CoV-2 spike
Abstract
The emergence of the betacoronavirus, SARS-CoV-2, the causative agent of COVID-19, represents a significant threat to global human health. Vaccine development is focused on the principal target of the humoral immune response, the spike (S) glycoprotein, which mediates cell entry and membrane fusion. SARS-CoV-2 S gene encodes 22 N-linked glycan sequons per protomer, which likely play a role in protein folding and immune evasion. Here, using a site-specific mass spectrometric approach, we reveal the glycan structures on a recombinant SARS-CoV-2 S immunogen. This analysis enables mapping of the glycan-processing states across the trimeric viral spike. We show how SARS-CoV-2 S glycans differ from typical host glycan processing, which may have implications in viral pathobiology and vaccine design.
Abstract
The emergence of the betacoronavirus, SARS-CoV-2, the causative agent of COVID-19, represents a significant threat to global human health. Vaccine development is focused on the principal target of the humoral immune response, the spike (S) glycoprotein, which mediates cell entry and membrane fusion. SARS-CoV-2 S gene encodes 22 N-linked glycan sequons per protomer, which likely play a role in protein folding and immune evasion. Here, using a site-specific mass spectrometric approach, we reveal the glycan structures on a recombinant SARS-CoV-2 S immunogen. This analysis enables mapping of the glycan-processing states across the trimeric viral spike. We show how SARS-CoV-2 S glycans differ from typical host glycan processing, which may have implications in viral pathobiology and vaccine design.
- 42,266
- 177,005
- Joined
- Oct 28, 2013
- 12,060
- 14,872
- Joined
- Jul 27, 2013
- 23,664
- 10,439
- Joined
- Oct 18, 2011
Watching MSNBC right now and the South Korean CDC have concluded people cannot get reinfected...
Herd immunity approach probably coming huh
Herd immunity approach probably coming huh
- 12,060
- 14,872
- Joined
- Jul 27, 2013
Gold’s Gym International Files to Restructure Under Chapter 11 Due to COVID-19 Pandemic
Gold’s Gym International, Dallas, filed for Chapter 11 on May 4 as a way to financially restructure the company after the worldwide shutdown of businesses from the COVID-19 pandemic affected the co | Gold’s Gym International is filing for financial restructuring through Chapter 11, affecting...
- 12,060
- 14,872
- Joined
- Jul 27, 2013
- 10,932
- 13,056
- Joined
- Sep 5, 2006
- 18,412
- 5,848
- Joined
- Dec 23, 2003
- 12,060
- 14,872
- Joined
- Jul 27, 2013
- 14,540
- 35,083
- Joined
- Jan 16, 2011
Folks better start getting used to all that colorful stuff in their plates.
- 141,328
- 168,127
- Joined
- Mar 16, 2010
So they're projecting daily death #'s equivalent to 9/11 within a month internally while encouraging and propping up restriction easing and 'opening up' externally/publicly at the same time...
Hell would be too kind for these people
- 12,060
- 14,872
- Joined
- Jul 27, 2013
ITALY DEATH TOLL FROM CORONAVIRUS OUTBREAK RISES BY 195 (VS 174 ON SUNDAY) TO 29,079 - OFFICIAL
TOTAL NUMBER OF CONFIRMED CASES OF CORONAVIRUS IN ITALY RISES BY 1,221 TO 211,938 -OFFICIAL
TOTAL NUMBER OF CONFIRMED CASES OF CORONAVIRUS IN ITALY RISES BY 1,221 TO 211,938 -OFFICIAL
- 14,540
- 35,083
- Joined
- Jan 16, 2011
Meanwhile, countries that have enacted strict testing and isolation policies are on the path to safely reopen their economies.
With testing, Iceland claims major success against COVID-19
HVAMMSTANGI, Iceland (AP) — Winter storms isolated the northern village of Hvammstangi from the rest of Iceland.
apnews.com
SMDH @ the US right now.
