- Jun 1, 2011
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- 79,471
In a nutshell
Hide Ya Wives, Hide Ya Kids: Worldwide Coronavirus Pandemic!
- Jul 27, 2013
- 12,092
- 14,916
we go to the beach all the time. memorial day was pretty packed and i’m guessing that july 4 will be just as bad. one of the main spots we go to has separated tide pools and we take one and stay away from other people. my wife is pretty paranoid so i’m not too worried about getting sick there. we’re not going to beaches where we are right next to others. i’m probably more at risk when i go to whole foods.
You guys love Makapu'u
aNYone
Supporter
- Dec 31, 2012
- 28,750
- 33,771
You know New Yorkers like I do.
I thought our summer would be canceled, but nah. NYers don't give a F.
People will have their summer one way or another and our rates will spike.
July 4th is about to be all bad.
- Nov 17, 2000
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- Mar 27, 2004
- 18,386
- 34,061
Covid-19 is just the disease caused by the virus SARS-CoV-2. The viral tests are to detect the virus, typically by PCR. This indicates the presence of virus particles, which could be an active infection (most likely) or could be remnants of a prior infection.
Antibody tests are to detect proteins made by your immune system in reaction to the virus. These antibody tests are not always specific though (you may have antibody against a different coronavirus but this test will still detect it).
- Apr 2, 2007
- 28,564
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- Oct 5, 2015
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Indeed they are, Houston's local government will always have their hands tied behind their back dealing with this virus WHILE we got those gullible idiots running the Governor and Lt. Governor chairs of the state of TX
Red level l | Harris County Judge announces new Stay Home Work Safe advisory
"I cannot stress enough the severity of this situation," Dr. Umair Shah said as Harris County moves to Level 1, which means COVID-19 is "severe & "uncontrolled."
www.khou.com
The fact that they have to BEG STUPID PEOPLE to not spread the virus INSTEAD of being empowered by Top State Officials to protect their citizens just shows how ****** Texas is.
- Dec 23, 2003
- 18,412
- 5,848
Inside the body, the coronavirus is even more sinister than scientists had realized
Cells hijacked by the coronavirus grow long, streaming tentacles to reach out to new victims, scientists found. This could complicate the search for a vaccine.www.latimes.com
By MELISSA HEALYSTAFF WRITER
JUNE 26, 2020
8 AM
The new coronavirus’ reputation for messing with scientists’ assumptions has taken a truly creepy turn.
Researchers exploring the interaction between the coronavirus and its hosts have discovered that when the SARS-CoV-2 virus infects a human cell, it sets off a ghoulish transformation. Obeying instructions from the virus, the newly infected cell sprouts multi-pronged tentacles studded with viral particles.
These disfigured zombie cells appear to be using those streaming filaments, or filopodia, to reach still-healthy neighboring cells. The protuberances appear to bore into the cells’ bodies and inject their viral venom directly into those cells’ genetic command centers — thus creating another zombie.
The authors of the new study, an international team led by researchers at UC San Francisco, say the coronavirus appears to be using these newly sprouted dendrites to boost its efficiency in capturing new cells and establishing infection in its human victims.
Their research was published Friday in the journal Cell.
The scientists also believe they have identified several drugs that could disrupt the viral takeover of cells and slow the process by which COVID-19 takes hold. These compounds, many of which were designed as cancer treatments, seem likely to work because they block the chemical signals that activate filopodia production in the first place.
Among the seven drugs they identified as potentially useful against COVID-19 are Silmitasertib, a still-experimental drug in early clinical trials as a treatment for bile duct cancer and a form of childhood brain cancer; ralimetinib, a cancer drug developed by Eli Lilly; and gilteritinib (marketed as Xospata), a drug in use already to treat acute myeloid leukemia.
The new research emerges from an ambitious effort to identify promising COVID-19 treatments using the science of “proteomics,” the interactions among proteins. Scientists set out to identify the chemical signals and cascading chain of events that take place when a virus meets and overtakes a host cell. Then, they look for drug compounds that could scramble those chemical signals and disrupt the process of infection.
Until now, the process by which the coronavirus was thought to infect cells was pretty run-of-the-mill for a virus: It found receptors on the surface of the cells that line humans’ mouth, nose, respiratory tract, lungs and blood vessels.
Like space invaders in a science fiction tale, the tiny virus was known to dock on the surface of the much larger cell. A viral landing party came aboard and hijacked the cell’s usual function, making it a factory for its replication.
The discovery that the coronavirus initiates the sprouting of filopodia in infected cells suggests that it has, at some point in its evolution, developed more than one way to ensure it gets passed quickly from cell to cell.
Typically, a rapid rise in infected cells will raise a victim’s viral load, make her feel sick and promote the transmission of the virus to other people. UC San Francisco’s Nevan Krogan, one of the paper’s senior authors, said there is much about the coronavirus that doesn’t match scientists’ expectations.
But the discovery of filopodia in coronavirus-infected cells suggests that this virus has developed more than one way to wheedle its way into cells and establish itself as a force to be reckoned with.
“It’s just so sinister that the virus uses other mechanisms to infect other cells before it kills the cell,” Krogan said. Other researchers include scientists from Mt. Sinai in New York, Rocky Mountain Labs in Montana (where these electron microscopy images were made), the Pasteur Institute in Paris and the University of Freiburg in Germany.
Cells sprouting filopodia not only look creepy. They keep some pretty nasty company as well.
Vaccinia, a member of the poxvirus family that causes smallpox, uses filopodia that sprout from infected cells to “surf” toward those cells and inject them with more viral particles, a 2008 study found. HIV and some influenza viruses have been known to use filopodia to enhance their ability to break and enter into cells. Many viruses alter the exoskeleton of the cells they infect, and inducing filopodia is one way they do it, said Columbia University virologist Angela L. Rasmussen. And while enhancing infection is one role they often play, there are many others.
But Krogan said even those viruses do not seem to set off the prolific growth of filaments that was seen by his colleagues on coronavirus-infected cells. The branching tentacles protruding from those cells were highly unusual, he said.
Columbia University microbiologist Stephen P. Goff urged caution in assuming that filopodia are necessarily behaving as a second mode of infecting cells with virus.
“It’s intriguing and a really cool observation,” Goff said. The study’s striking images show that the filopodia contain a lot of virus and that in the lab, inhibiting their growth seemed to reduce viral replication. This strongly suggests that filopodia are somehow amping up the virus’ ability to infect cells, he acknowledged.
“But we don’t yet know what stage [of infection] is affected” by the strange protrusions, he said. “It will be great fun to find out.”
“It will be great fun to find out.”
what the hell is wrong with this guy
this is downright scary
i really can't see us ever going back to how we lived before this plague
- Mar 16, 2010
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- Jul 27, 2013
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- Apr 21, 2007
- 7,815
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Thought it was another amber alert but they just sent public safety alerts to all Houston residents.
- Jul 18, 2012
- 34,180
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Damn I wanted to go to London this year again but looks like that isnt gonna happen.
- Mar 27, 2004
- 18,386
- 34,061
Didn't they Brexit? Maybe you could still go.
- Mar 30, 2007
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- Jun 1, 2011
- 107,064
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Thought it was another amber alert but they just sent public safety alerts to all Houston residents.
Yea I got this too. Hidalgo was trying her best to help limit stuff, but Abbott didn’t give one single **** and was only thinking about Memorial Day weekend money being made. Abbott was very happy to make Texas the guinea pig for reopening, and this is the result. Now all those goofy asses from other states that flocked here talking about “tExAs Is OpEn”, well, now you’re the the reason Texas will be back under restrictions soon enough.
- Aug 5, 2007
- 16,549
- 21,147
yup but make no mistake, if our numbers were higher, we'd probably not be going there. I have other spots where we'd be the only ones around but my son loves makapu'uYou guys love Makapu'u
aepps20
Supporter
- Feb 8, 2004
- 42,549
- 90,784
In a nutshell
GORGEOUS FAM
- Jul 27, 2013
- 12,092
- 14,916
- Dec 23, 2003
- 18,412
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CNN just said 40,000 cases in the US today
thekillerj23
Supporter
- Apr 4, 2007
- 10,291
- 11,506
It already has, stepped out last week, not one person had mask on, every spot such as federales, paradise park was packed with people drinking like nothing changed. Only time people had mask on was the fake care to get in the spot. Now with Phase 4 open, so many people already posting videos of them at the gym, eating inside.
- Apr 21, 2007
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Opening the bars is the only problem huh? lol Clown.
- Oct 5, 2015
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- Mar 27, 2004
- 18,386
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- Jul 31, 2004
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- Apr 2, 2007
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