- Jul 18, 2012
- 34,180
- 40,100
NYC will go phase 3 on July 6th. Meh too early. Phase 2 JUST started, why we going to phase 3 already?
We gonna go back to number 1 REAL quick.
We gonna go back to number 1 REAL quick.
Hide Ya Wives, Hide Ya Kids: Worldwide Coronavirus Pandemic!
- Sep 5, 2012
- 2,250
- 1,311
- Jul 22, 2012
- 37,343
- 32,196
At this rate, I'm not optimistic that my daughter will start Pre-K in August.
aepps20
Supporter
- Feb 8, 2004
- 42,545
- 90,780
He probably will then he will blame Hispanics. Scumbag is a deplorable.
- Feb 23, 2010
- 23,400
- 26,477
- Oct 28, 2013
- 42,726
- 178,516
aepps20
Supporter
- Feb 8, 2004
- 42,545
- 90,780
Scott Burrell obviously didn't approve this ad.
- Feb 24, 2009
- 11,540
- 7,443
That’s wild. Way too quick but they are going by numbers and charts. Should still be a 2 week waiting period AFTER we hit the numbers needed for another phase to fully go into it.
Just to make sure it’s not a false call
- Oct 7, 2007
- 7,589
- 7,468
Are you only in character in the Politics thread? Genuinely asking lol
- Jul 27, 2013
- 12,092
- 14,916
Inside the body, the coronavirus is even more sinister than scientists had realized
Cells hijacked by the coronavirus grow long, streaming tentacles to reach out to new victims, scientists found. This could complicate the search for a vaccine.
www.latimes.com
By MELISSA HEALYSTAFF WRITER
JUNE 26, 2020
8 AM
The new coronavirus’ reputation for messing with scientists’ assumptions has taken a truly creepy turn.
Researchers exploring the interaction between the coronavirus and its hosts have discovered that when the SARS-CoV-2 virus infects a human cell, it sets off a ghoulish transformation. Obeying instructions from the virus, the newly infected cell sprouts multi-pronged tentacles studded with viral particles.
These disfigured zombie cells appear to be using those streaming filaments, or filopodia, to reach still-healthy neighboring cells. The protuberances appear to bore into the cells’ bodies and inject their viral venom directly into those cells’ genetic command centers — thus creating another zombie.
The authors of the new study, an international team led by researchers at UC San Francisco, say the coronavirus appears to be using these newly sprouted dendrites to boost its efficiency in capturing new cells and establishing infection in its human victims.
Their research was published Friday in the journal Cell.
The scientists also believe they have identified several drugs that could disrupt the viral takeover of cells and slow the process by which COVID-19 takes hold. These compounds, many of which were designed as cancer treatments, seem likely to work because they block the chemical signals that activate filopodia production in the first place.
Among the seven drugs they identified as potentially useful against COVID-19 are Silmitasertib, a still-experimental drug in early clinical trials as a treatment for bile duct cancer and a form of childhood brain cancer; ralimetinib, a cancer drug developed by Eli Lilly; and gilteritinib (marketed as Xospata), a drug in use already to treat acute myeloid leukemia.
The new research emerges from an ambitious effort to identify promising COVID-19 treatments using the science of “proteomics,” the interactions among proteins. Scientists set out to identify the chemical signals and cascading chain of events that take place when a virus meets and overtakes a host cell. Then, they look for drug compounds that could scramble those chemical signals and disrupt the process of infection.
Until now, the process by which the coronavirus was thought to infect cells was pretty run-of-the-mill for a virus: It found receptors on the surface of the cells that line humans’ mouth, nose, respiratory tract, lungs and blood vessels.
Like space invaders in a science fiction tale, the tiny virus was known to dock on the surface of the much larger cell. A viral landing party came aboard and hijacked the cell’s usual function, making it a factory for its replication.
The discovery that the coronavirus initiates the sprouting of filopodia in infected cells suggests that it has, at some point in its evolution, developed more than one way to ensure it gets passed quickly from cell to cell.
Typically, a rapid rise in infected cells will raise a victim’s viral load, make her feel sick and promote the transmission of the virus to other people. UC San Francisco’s Nevan Krogan, one of the paper’s senior authors, said there is much about the coronavirus that doesn’t match scientists’ expectations.
But the discovery of filopodia in coronavirus-infected cells suggests that this virus has developed more than one way to wheedle its way into cells and establish itself as a force to be reckoned with.
“It’s just so sinister that the virus uses other mechanisms to infect other cells before it kills the cell,” Krogan said. Other researchers include scientists from Mt. Sinai in New York, Rocky Mountain Labs in Montana (where these electron microscopy images were made), the Pasteur Institute in Paris and the University of Freiburg in Germany.
Cells sprouting filopodia not only look creepy. They keep some pretty nasty company as well.
Vaccinia, a member of the poxvirus family that causes smallpox, uses filopodia that sprout from infected cells to “surf” toward those cells and inject them with more viral particles, a 2008 study found. HIV and some influenza viruses have been known to use filopodia to enhance their ability to break and enter into cells. Many viruses alter the exoskeleton of the cells they infect, and inducing filopodia is one way they do it, said Columbia University virologist Angela L. Rasmussen. And while enhancing infection is one role they often play, there are many others.
But Krogan said even those viruses do not seem to set off the prolific growth of filaments that was seen by his colleagues on coronavirus-infected cells. The branching tentacles protruding from those cells were highly unusual, he said.
Columbia University microbiologist Stephen P. Goff urged caution in assuming that filopodia are necessarily behaving as a second mode of infecting cells with virus.
“It’s intriguing and a really cool observation,” Goff said. The study’s striking images show that the filopodia contain a lot of virus and that in the lab, inhibiting their growth seemed to reduce viral replication. This strongly suggests that filopodia are somehow amping up the virus’ ability to infect cells, he acknowledged.
“But we don’t yet know what stage [of infection] is affected” by the strange protrusions, he said. “It will be great fun to find out.”
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- May 12, 2008
- 36,573
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Paywall. Can you screenshot itInside the body, the coronavirus is even more sinister than scientists had realized
Cells hijacked by the coronavirus grow long, streaming tentacles to reach out to new victims, scientists found. This could complicate the search for a vaccine.
- Jul 27, 2013
- 12,092
- 14,916
- Feb 24, 2009
- 11,540
- 7,443
Might be a silly question but Does the test they are giving everyone to determine if they are positive or negative detect Sars-COV2 or Covid-19?
And does the Antibodies test detect Sars-COV2 or Covid-19?
I’m wondering if some of these people that test positive or have antibodies but never showed symptoms have the virus laying dormant in their system
And does the Antibodies test detect Sars-COV2 or Covid-19?
I’m wondering if some of these people that test positive or have antibodies but never showed symptoms have the virus laying dormant in their system
- Dec 23, 2003
- 18,412
- 5,848
Info for new yorkers
- Jul 27, 2013
- 12,092
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SAN FRANCISCO MAYOR BREED: TO DELAY REOPENINGS PLANNED FOR MONDAY
elpablo21
Supporter
- Feb 11, 2008
- 106,402
- 195,796
Seeing the Rethugs all of a sudden come out in favor of masks is rich
- Jun 20, 2014
- 5,083
- 7,592
CA Gov Newsom is putting Imperial County back on stay at home orders... more to come SOON, I'm sure.
- Oct 28, 2013
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- Jun 20, 2014
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I think I understand what you're asking... The antigen test that is being administered most commonly is specifically testing for the presence of covid-19 active in people who are CURRENTLY infected with the virus. The antibody test looks for antibodies present in the blood of recovered patients to determine if they were infected previously. As far as I know, there is no such thing as having "the virus laying dormant" in your system. There can still be dead viral particles in your system for many months after you have "recovered" which can show up in the antigen test, but does not indicate that you are currently infected. This was leading to some confusion about people being "reinfected" after previously testing negative. I hope this is clear.
- Jul 18, 2012
- 34,180
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And look how fast those numbers went up. Now people are wearing masks yes but not everyone. No idea if it’ll go back to March levels but we were at what, 800 deaths a day for like a month? Unacceptable.
elpablo21
Supporter
- Feb 11, 2008
- 106,402
- 195,796
- Aug 5, 2007
- 16,548
- 21,146
we go to the beach all the time. memorial day was pretty packed and i’m guessing that july 4 will be just as bad. one of the main spots we go to has separated tide pools and we take one and stay away from other people. my wife is pretty paranoid so i’m not too worried about getting sick there. we’re not going to beaches where we are right next to others. i’m probably more at risk when i go to whole foods.
aepps20
Supporter
- Feb 8, 2004
- 42,545
- 90,780
aepps20
Supporter
- Feb 8, 2004
- 42,545
- 90,780
- Jul 16, 2002
- 30,787
- 5,784
My fellow NYers, just enjoy this summer. We have one of the lowest rates in America right now. Honestly, I'm glad that we are relatively low for now. Just be responsible, wash your hands, always carry hand sanitizer with you, wear a mask in public spaces. Just enjoy this summer before the inevitable second wave hits later. No point in looking at numbers now in NY and worrying. We went through a scary and depressing time earlier, just enjoy the time right now.
