Meow wolf is a unique, fully immersive art exhibit.
Get Mexican food, especially something with green Chile (like a gravy sauce). La Loma is my favorite downtown (slightly expensive), and D'Corazon (cheaper and smaller space). Also a lot more authentic places exist, the 2 I mentioned might be a little more americanized.
Always cool to see Red Rocks amphitheater in person. It's only 20-25 minutes from downtown.
Berkeley, LoHi, RiNo, Cherry Creek neighborhoods are walkable areas with bars and restaurants. Downtown has some options, esp closer to Coors Field but neighborhoods have the more unique places. Few Speakeasy type places, some food halls like Denver Central Market / Avanti / Stanley Marketplace.
If you are looking for something specific and I can add