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I have a couple of relatives who were holding out on the vaccine. Wonder what they’re going to do now and I wish I could be there when they heard the news
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I have a couple of relatives who were holding out on the vaccine. Wonder what they’re going to do now and I wish I could be there when they heard the news
There's been a strong correlation between Israel's Delta surge and the booster campaign that crushed it. If you're young and healthy and have gotten 2 doses you're probably still well protected against severe disease and death, but the benefits of getting boosted far outweigh the risks, IMO. Based on what I've seen and heard from reputable/trusted sources, you shouldn't be considered fully vaccinated until you've had 3 doses.I come in Peace: Have there been any official studies proving that a booster is necessary after 6-8 months.
Is there hard evidence backing this waning immunity theory and not just the fact that a lot people have contracted Covid after being fully vaccinated.
First time I've heard this explanation, but it makes sense. Gottlieb states that Pfizer found the downside of a variant specific booster for COVID is that although it likely provides better immune response against the targeted variant, it doesn't seem to give as broad of an immune response against other strains of the virus that are either circulating simultaneously or that will undoubtedly come afterward.
I think that makes sense - and it’s basically the argument I use against “natural immunity” - yes you’ll have antibodies, but only to a specific strain rather than the broad protection of the vaccine - as long as the virus doesn’t mutate away from the specific characteristic the vaccine is effective against.
It’s also related to the reason why you need a flu shot each year - immunity from prior infection doesn’t help against other strains. Doesn’t mean the vaccine is ineffective it’s just the nature of a virus like that.
Please entertain my layman's question about so-called "natural immunity" being less effective against variants. If getting infected provides antibodies against S(pike), N(eucleocapsid?), and E(nvelope) (proteins?) and vaccine only provides antibodies against S, wouldn't infection induced immunity theoretically be better because it provides a wider array of antibodies in case a variant changes enough? In the case of Omicron, the spike has mutated pretty significantly, but maybe N and E are still recognized? Sorry if this doesn't make sense, but I never took any science classes after high school.
Please entertain my layman's question about so-called "natural immunity" being less effective against variants. If getting infected provides antibodies against S(pike), N(eucleocapsid?), and E(nvelope) (proteins?) and vaccine only provides antibodies against S, wouldn't infection induced immunity theoretically be better because it provides a wider array of antibodies in case a variant changes enough? In the case of Omicron, the spike has mutated pretty significantly, but maybe N and E are still recognized? Sorry if this doesn't make sense, but I never took any science classes after high school.
A few studies have investigated the potential of rCoVs with a mutated E or lacking E, specifically focussing on SARS- and MERS-CoV, as live attenuated vaccine candidates with some promising results [34, 36, 165, 249, 250]. Vaccinated animal models developed robust immune responses, both cellular and humoral, and were protected against infective challenges. This shows that CoV vaccines with mutated or deficient in E can potentially be used for prophylactic treatment, but the duration of immunity does not seem to have been established yet.
SARS-CoV-2 infection causes respiratory insufficiency and neurological manifestations, including loss of smell and psychiatric disorders, and can be fatal. Most vaccines are based on the spike antigen alone, and although they have shown efficacy at preventing severe disease and death, they do not always confer sterilizing immunity. Here, we interrogate whether SARS-CoV-2 vaccines could be improved by incorporating nucleocapsid as an antigen. We show that, after 72 h of challenge, a spike-based vaccine confers acute protection in the lung, but not in the brain. However, combining a spike-based vaccine with a nucleocapsid-based vaccine confers acute protection in both the lung and brain. These findings suggest that nucleocapsid-specific immunity can improve the distal control of SARS-CoV-2, warranting the inclusion of nucleocapsid in next-generation COVID-19 vaccines.
Even has the mask tan on his face.
Only surprising thing there is that a guy who went to an anime convention actually has friends IRL to infect.