Deadpool is just fine in his own world.
I think what they can do with him now is instead of wondering why the xmen are never around he will wonder why the Avengers are ever around and they can make running jokes about that in his movies
He can explain it at the beginning of the movie: 'well kids as you all know the rights to me changed hands. I live in the mcu now but I never seem to find the Avengers when I need them'
Collosus and Nuclear Warhead can keep showing up and Deadpool can make side comments about them like : 'I like that you're still in my movies but I don't think Kevin Feige is going to use you in his other movies'
And instead of walking around in an empty school, Deadpool will walk around in an empty avengers headquarters