I very much disagree... you couldn't pay me to drive from BOSTON to BANFF.
That is 40+ hours of driving, over 2500 miles... the majority of which is through absolute no-man's land. There isn't **** to see on that drive from Niagara Falls until you hit the Rockies inside of Canada - aka like 80%+ of the drive. 40 hours of combined driving means that just to get there, you are taking at least 3 full 12-hour+ days of driving, not even including stopping for gas, food, sleep. Not sure the longest you've ever driven, but 12+ hours multiple days in a row isn't going to be comfy - especially if you're trying to hike and sleep on the ground in between each drive.
If I were you, I'd either focus on NP's on the East Coast that you can road-trip to... or figure out a plan to fly to Banff (or PNW) and rent a car / place to stay, and make day trips from a "base camp" (whether that is camping, or hotel / airbnb). The problem with this is that if you fly you won't be able to bring your vehicle and the gear you need (depending on how much you have and want to bring). You can also rent those adventure Sprinter Vans that come decked out with a lot of gear and room to car camp.
You could fly into Seattle, and hit Olympic NP + North Cascades NP + Mount Ranier NP. Then hop over the border and hit Pacific Rim NP + Gulf Islands NP, and then make the 9+ drive over to Banff NP + Kootenays NP + Jasper NP. You'd need at minimum, like 10-12 days to make that a trip (if you wanted to hit all 8 of the NP's I listed, in one road trip).
Again, depends on how much time you have and want to spend. Even if you only spent 1 day at each park... you need time to drive between each location, find and setup camp if you don't pre-book, time to eat / plan / prep for the next days, etc.
But that's like, just my opinion, maaaaan